14th International Conference on Structural Biology (CSE) AS

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14th International Conference on Structural Biology

About Conference

Biochemistry Conferences cordially invite you all to attend the 14th International Conference on Structural Biology during September 24-26, 2018 at Berlin, Germany. This is an amazing opportunity for the participants from different Universities and Institutions to interact with the most proficient Scientists world-wide. Structural Biology 2018 will be a global stage for sharing information and ability from both scientific and industrial groups. The conference will impact an attractive moment to interact with professionals in the research field and therefore it takes a delight in opening a gate to meet young researchers and potential speakers where they can demonstrate their novel research and contributions in the field of structural biology and biophysics.

We are sure Structural Biology 2018 will be a marvellous open door for the global group to express their thoughts and add a typical vision for future research and prompts collaboration among researchers taking an interest.

Our Conference will provide a perfect platform addressing:

  • Commendable talks by the first-string of the global scientific community.
  • Sterling workshop sessions.
  • Remarkable Awards and Global Recognition to meritorious Researchers.
  • Global Networking with 50+ Countries.
  • Novel Techniques to Benefit Your Research.
  • Global Business and Networking Opportunities.
  • Exquisite platform for exhibiting your by-products and International Sponsorship

Scientific Sessions

Structural Biology 2018 is an excellent opportunity to learn and discuss about the recent innovations in the field and also the methods such as X-ray diffraction, NMR, electron microscopy,

Track 1: Structural Biology

Structural biology is defined as a branch of molecular biology which deals with biophysics and biochemistry regarding the molecular structure of biological macromolecules. It also provides information about their structural alterations and how it affects their function. This process of determination of structures of proteins, nucleic acids may take years as the shape, size and assemblies of these molecules may be altering the function. Biologists show great interest as they deal with the determination of the function of macromolecules. This process of determination of structures of proteins, nucleic acids may take years as the shape, size and assemblies of these molecules may be altering the function.

  • 1-1 Biochemistry
  • 1-2 Biophysics
  • 1-3 Alternations in Protein Structure
  • 1-4 Biological system
  • 1-5 Dimensions in Structure determination
  • 1-6 Structural modifications in nucleic acids
  • 1-7 Proteomics
  • 1-8 Call-map proteomics
  • 1-9 Expression proteomics

Track 2: Determination of 3D structures

Biomolecules are too small to observe in detail, even with the most advanced light microscopes. These may include macro and micro molecules along with natural products. These may be endogenous and exogenous in nature. Structural biologists generally use these methods to determine the structures of identical molecules in a huge quantity at a time. Scientists use these methods to study the “real states” of the biomolecules. Some of the best methods include X-ray crystallography, Cryo-Electron Microscopy and Nuclear Magnetic Resonance.

  • 2-1 X-ray crystallography
  • 2-2 Cryo-Electron Microscopy
  • 2-3 Nuclear Magnetic Resonances
  • 2-4 Powder diffractometry
  • 2-5 Mass spectroscopy
  • 2-6 Dual polarisation interferometry
  • 2-7 Multi-angle light scattering
  • 2-8 Ultra-fast laser spectroscopy

Track 3: Computational Approaches in Structural Biology

Computational approaches include most of the aspects of bio-informatics and are considered as a boon for structural biology. The method of molecular structure determination by experimental way is time-consuming and costly. To overcome these constraints, computational approaches like ab-initio modelling, homology modelling, advanced fold recognition and threading method are used.

  • 3-1 Homology modeling
  • 3-2 Ab-initio method
  • 3-3 Threading
  • 3-4 Discoveries through computational approaches

Track 4: Structure Prediction by Hybrid Approach

This is a cost effective approach for determining the protein structure. The computational prediction methods, such as initiating fragment assembly, advanced fold recognition, composite approaches, and molecular docking are regularly applied in recent times to expand our understanding of protein structures. Nevertheless, predicted structures are not given the same credits as their experimental counterparts. Hybrid approach is a channel to overcome these disadvantages, by incorporating limited experimental measurements, reliable structures can be computed and unlikely predictions are eliminated. The current researches are showing great interest in this method of approach.

  • 4-1 Hybrid of experimental methods
  • 4-2 Hybrid of computational methods
  • 4- 3 Hybrid approaches in complementing high-resolution structural biology
  • 4-4 Determining protein complex structures
  • 4-5 Bottom-up integration of atomic detail crystallography
  • 4-6 NMR structures

Track 5: Sequence Analysis

Sequence analysis can be explained as a process of exposing DNA, RNA or peptide sequence to a wide range of analytical methods in order to understand its structure, function and evolution. The methods include sequence alignment, biological databases. The sequences are being compared to that of the known functions, harmoniously to understand the biology of the organism which gives the new sequence. Synergistic use of three-dimensional structures and deep sequencing is done to realize the effect of personalized medicine.

  • 5-1 Profile comparison
  • 5-2 Sequence assembly
  • 5-3 Gene prediction
  • 5-4 Protein Structure Prediction
  • 5-5 Membrane protein structure and function using complementary methods
  • 5-6 Deep sequencing for protein structure determination
  • 5-7 Synergistic use of 3D structures and deep sequencing to realize personalized medicine
  • 5-8 Deep sequencing for cancer studies
  • 5-9 Deep sequencing of HIV

Tracks 6: Structural Enzymology

Enzymes play a crucial role in signalling the cellular and metabolic pathways. Research works are going on to identify, how the enzymes function at molecular and atomic level by combining the modern biochemistry and structural biology.

  • 6-1 Protein engineering
  • 6-2 Protein prenylation techniques
  • 6-3 Steady state kinetics
  • 6-4 Calorimetric methods
  • 6-5 Chemical analyses

Track 7: Structural Biology Databases

A database is an organised collection of data. As a result of enormous research which is being done in Structural biology massive data has been produced. In order to assemble the data in a catalogued manner, bioinformatics databases are used. Various databases have been created to store biological data, such as sequence databases, structure databases, signalling pathway databases, etc.

  • 7-1 Protein data bank
  • 7-2 Electron microscopy data bank
  • 7-3 Protein structure classification database
  • 7-4 Classification of structural database
  • 7-5 Classification of protein structure

Track 8: Structural Biology in Cell Signalling

Generally cells communicate by the release of chemical signals. They are often secreted from the cell and released into the extracellular space. Regulation of gene expression comprises a comprehensive range of mechanisms that are used by cells to regulate the production of specific gene products, and is familiarly termed as gene regulation. Sophisticated programs of gene expression are extensively observed in biology, for example to trigger developmental pathways, adapt to new food sources, or respond to environmental stimuli. Eventually the gene expressions can be adjusted, starting from transcription, initiation to post translation modification of a protein.

  • 8-1 Protein crystallography
  • 8-2 Adrenergic receptor
  • 8-3 G-protein-coupled receptor
  • 8-4 GPCR
  • 8-5 Protein structure

Track 9: Molecular Modelling

Molecular modelling constitutes all the hypothetical methods and computational procedures used to mimic the behaviour of macromolecules. These techniques are used in diverse fields of drug design, computational chemistry, materials science and computational biology for studying macromolecular systems ranging from small to large biological systems. In order to simulate the interactions between the atoms, for further understanding of the properties, molecular simulation uses powerful techniques. Such simulations involve methods that range from very detailed quantum mechanical calculations on atoms to coarse-grained classical dynamics of large groups of molecules on a timescale of milliseconds or longer.

  • 9-1 Protein folding
  • 9-2 Enzyme catalysis
  • 9-3 Protein stability
  • 9-4 Conformational changes associated with bio-molecular function
  • 9-5 Molecular recognition of proteins
  • 9-6 DNA and membrane complexes

Tract 10: Molecular Dynamics

Molecular dynamics (MD) deals with the study of physical movements of the atoms and molecules using computer simulation method, so it is referred to as one of the type of N-body simulation. The atoms and molecules are allowed to interact for a fixed period of time, giving a view of the dynamic evolution of the system. The trajectories of atoms and molecules are commonly determined by solving them numerically using Newton’s equations of motion for a group of collaborating particles. The forces between the particles and their potential energies are calculated using inter-atomic potentials or molecular mechanics force fields.

  • 10-1 Steered molecular dynamics (SMD)
  • 10-2 Potentials in ab initio methods
  • 10-3 Coarse-graining and reduced representations
  • 10-4 Hybrid QM/MM

Track 11: Structural Biology in Drug Design

Drug design is an innovative process to asset new medication based on the knowledge of biological target. Drug is most commonly a small molecule that inhibits or activates the function of a biomolecule, which in turn outcomes in a therapeutic benefit to the patient. Drug design commonly but not essentially relies on computational techniques. This type of modelling is often mentioned to as computer-aided drug design. Drug design that depends on the knowledge of the 3D structure of the target is known as structure-based drug design. The main methods available for drug design are structure based drug design and ligand based drug design.

  • 11-1 Drug targets
  • 11-2 Computer-aided drug design
  • 11-3 Ligand-based design
  • 11-4 Structure-based design
  • 11-5 Binding site identification
  • 11-6 Scoring functions

Track 12: Frontiers in Structural Biology

The main focus of a structural biologist is protein structure determination and drug design. Protein plays an important role in human body. Living things would not exist without proteins. The proteins are usually involved in all forms of expressions of the living organism. Most of the proteins are evolved in providing structure to the cell while the others tend to bin and carry vital molecules all through the body. Some proteins are involved in biochemical reactions in the body which are termed as enzymes. Others are involved in muscle contractions and immunity. Structure determination of proteins has always been a challenging filed. The complex areas in the field include viruses, pathogens, membrane proteins and signalling pathways. Novel progressions are being done in the arenas of nano-patternig and multi-scale modelling of cell signalling proteins.

  • 12-1 Membrane proteins
  • 12-2 Pathogens and viruses
  • 12-3 Nano patterning
  • 12-4 Multi-scale modeling for signalling proteins
  • 12-5 Macromolecular designing

Track 13: Structural Biology in Cancer Research

The main aim of integrating structural biology data into cancer research is to design and discover novel and effective drugs to cure the disease. Structural biology combined with molecular modelling mainly aims at drug designing. Consequently, a number of Structural Biologists are conducting cancer research, to speed-up the process of understanding the mechanism of biomolecules in order to improve the newer cancer therapies.

  • 13-1 Role of proteosomes
  • 13-2 Cop9 signalosome in protein degradation
  • 13-3 Transcription regulation

Track 14: Structural Biology Complexity Arenas

Structural biology aims at understanding biomolecules at atomic level. All aspects in structural biology research seem to be complex. Research methods have proved to be successful in solving many of the complexities such as protein structure determination, functional annotations and drug designing. Though protein structures are solved on a large scale, the gap between available sequence data and structure data is enormous. Bridging this gap is one of the main challenges.

  • 14-1 Nano-machinery
  • 14-2 Network signalling
  • 14-3 Protein folding

Track 15: Recent Advancements in Structural Biology

Structural biology is one of the progressing fields. In the course of time many developments have been taking place. Huge numbers of solved structures have exaggerated rapidly. The field of drug design and drug discovery has been advanced. Functional annotations are another field where progressions are rapidly evolving. Alterations in order to improve the effectiveness of prevailing tools can also be noted. Remarkable advances have been made in the areas of technical imaging and advancement of hybrid methods to understand the structure and function of proteins.

  • 15-1 Structure determination
  • 15-2 Technological Advances in Existing Methods
  • 15-3 New and Potentially Disruptive Technologies
  • 15-4 Advances in Drug Design
  • 15-5 Advances in Tool Development
  • 15-6 Advances in imaging Technologies

Please contact the event manager Marilyn (marilyn.b.turner@nyeventslist.com ) below for:
- Multiple participant discounts
- Price quotations or visa invitation letters
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