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Naresh Chennamsetty, BMS: Determining Solubility of APIs and Intermediates

Scale-up Systems

Tuesday, December 6, 2011 from 9:00 AM to 10:00 AM (EST)

Naresh Chennamsetty, BMS: Determining Solubility of...

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The design of efficient pharmaceutical processes such as reaction and crystallization is critically dependent on choosing an optimal solvent system.  Selecting the solvent system requires the knowledge of the solubility of APIs or intermediates in several solvents and solvent mixtures.  However, even with the use of automation and material sparing techniques, the direct experimental measurement of solubility in all possible solvents and solvent mixtures and as a function of temperature is often impractical and inefficient due to the limited quantities of material available during the early stages of process development.

We present an empirical-modeling workflow to estimate solubility and we evaluate different solubility models.  We compare the performance of NRTL-SAC with two other alternative models: PC-SAFT (Perturbed-Chain Statistical Associating Fluid Theory) as implemented by Scienomics and regressed-UNIFAC (UNIversal quasichemical Functional-group Activity Coefficients) as implemented by DynoChem.  Unlike the standard UNIFAC, the regressed-UNIFAC from DynoChem treats the solute as a single functional group.  Furthermore, we evaluate the predictive capabilities of these three different models and discuss their unique strengths, limitations, and accuracy.  We also discuss the FTE (Full Time Equivalent) savings obtained through our combined automated parallel experiment and modeling approach in the pharmaceutical process design. 

Registration is open to DynoChem customers and prospective customers from industry, academia and government.

Have questions about Naresh Chennamsetty, BMS: Determining Solubility of APIs and Intermediates? Contact Scale-up Systems

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